Canine Blastomycosis

Blastomycosis is a serious systemic fungal disease that primarily infects dogs and people. While there have been reported cases in a variety of animals including cats and horses, they are relatively rare. Dogs are 10 times more likely to develop the disease than people are. A big factor in determining which dogs get infected is directly related to their lifestyle and where they live.
Risk factors include living or spending time near water, disturbing the soil during excavation, construction, or gardening. Dogs that dig increase their risk, hunting dogs and hounds are infected much more frequently than house pets and younger dogs are more commonly infected, with the highest prevalence seen in 2-year-old dogs. But any dog can contract blastomycosis.
Blastomycosis is caused by a microscopic fungus that lives in sandy soil in close proximity to water and periodically releases invisible spores into the air, which dogs, other animals and people can inhale. Conditions must be perfect for the fungus to survive. The fungus occurs more frequently in the fall around wetlands and waterways, but it can occur in urban and suburban areas, too. The spores can travel in the wind for at least half a mile.
Blastomycosis cannot be transmitted from an infected animal to a healthy animal or from an animal to a person, it can only be acquired from inhaling the spores in the soil.
Blasto can be found in the Upper Midwest, Mid-Atlantic, Southeastern states, and in the Ohio, Missouri and Mississippi River valley and parts of Quebec, Manitoba, and Ontario. Blastomycosis is often found in small pockets instead of being widespread. It is believed that the range of blastomycosis continues to grow.I have seen several cases of Blastomycosis in Central IL where I live by the Vermillion River.
Symptoms Of Blastomycosis
Infection occurs from the dog inhaling the spores that are found in the soil. Blasto can infect multiple organs and produce various symptoms. At body temperature, the spores turn into yeasts and infects the lungs. Once Blastomycosis establishes itself in the lungs, it then enters into the bloodstream, blasto will spread to the skin, bones, joints, lymph nodes, kidneys, eyes or brain. Dogs show symptoms within a few weeks to a few months after inhaling spores.
Symptoms include:
Loss of appetite
Weight loss
Persistant fever
Cough
Shortness of breath
Open sores or lumps that drain blood or pus
Blood in urine
Pain in a limb or joints, lameness
Cloudy, bulging, or red painful eyes
Enlarged lymph glands
Seizures or other signs of brain infection
Up to 85% of dogs with blastomycosis have lung lesions and an accompanying dry, harsh cough. Forty percent of dogs with blastomycosis have eye lesions including uveitis, retinal detachment, and hemorrhaging into the eye. Skin lesions that are ulcerated and draining are found in 20 to 40% of the infected dogs. Bone involvement and resulting lameness is present in about 30% of infected dogs.
Treatment for Blastomycosis
Relatively few animals are exposed and infected with blastomycosis, but those that are require treatment. There are several treatment options. The most common treatment is the oral administration of the antifungal drug Itraconazole. This drug usually needs to be given daily for 60 to 90 days. It is a human drug and can be very expensive, particularly for a large dog, but it is currently the safest and most effective way to treat blastomycosis.
For dogs that can not tolerate or do not respond to Itraconazole, the injectable drug Amphotericin B can also be used. This drug is given intravenously several times a week. Because it is more toxic than Itraconazole, it is administered under close veterinary observation.
Ketoconazole (Nizoral) is occasionally used in milder cases where cost is a strong consideration. It is not as effective and is slightly more toxic than Itraconazole, and therefore, is not usually the first choice in treatments.
Most animals will have severe appetite loss and must be encouraged to eat or be force fed the first 7-14 days. Blastomycosis can be rapidly fatal if not diagnosed and treated promptly. Even with proper treatment, many dogs do not recover from the infection and relapses can occur.
Prognosis
Prognosis for any animal diagnosed with blastomycosis is guarded to good. Approximately 50% to 75% of affected dogs recover when treated with itraconazole or an amphotericin-ketoconazole combination. The two most important prognostic indicators are brain involvement and severity of lung disease.
Prognosis is poor for dogs with brain involvement, but some can be successfully treated. Approximately 50% of the dogs with severe lung disease die from pulmonary failure, but if the dog survives the first 7 to 10 days of therapy, the prognosis improves.
Eyes that are severely affected may not respond well to the treatment because the medication does not penetrate eyes very well. Significantly affected eyes may require enucleation (removal of the eyeball).
Relapses occur in approximately 20% of animals that survive treatment. Relapse after apparently successful treatment typically occurs in the first 6 months but can occur up to 15 months post-treatment. Recurrence of disease is treated with another 60 to 90 day regimen of ITZ. Recurrence usually occurs due to reactivation of a residual site of infection. Retreatment has an 80% or greater chance of producing a cure.
Can Blastomycosis Be Prevented?
There is currently no vaccine available to protect against blastomycosis. Because of the isolated distribution pattern of blastomycosis, it is difficult to determine where the source of most infections come from, and therefore, avoidance is almost impossible.
Awareness of the disease and its symptoms is the best defense against Blasto.
Limiting the amount of time a dog spends in the woods, particularly near water sources may reduce the incidence.
Avoid taking your dog to known blasto areas, places with disturbed areas of moist soil and prevent digging.
Recognizing the symptoms, and seeking prompt veterinary attention are the best ways to deal with this disease.
The information for this article was obtained from The University of Georgia College of Veterinary Medicine. and VeterinaryPartner.com